Random non-structured thought dump!
First thing I noticed was the music, I've heard it somewhere before and I immediately wanted an option to turn it off (yeah yeah, I'm sure you have sound controls in there but for some reason it really irked me).
I would like to have seen a multiple damaging effect (hero choice), just to see how it plays out.
If you're making this "pass and play" how are you handling card draws for others? e.g. Fleet of Foot. Do you have to pass the pad around, while it waits for some sort of OK sign to move on to the next person? Does it just display what each person drew on their turn?
There was no effect to show that everybody gained a hit point when Motivational Charge was used (it did happen though), I would like to see both a plus and a minus when people gain or lose HP.
I think the discard pile is too far off screen, I would prefered it below the deck as there is screen space available there. With multiple effects that allow you to dig something out of your trash you don't want to spend time trying to select the tiny bit of the screen to look through your trash. Tachyon in particular always wants to know what's in the trash (an automated burst count for her would be awesome!)
Can you look at someone else's hand during your turn? I would like to know if Fanatic is going to play End of Days before I play Impromtu Invention!
Hmmm, on a similar note, do you get to look at your hand before the first villain turn?
Is there any way you can make the HP numbers on the cards change? I don't want to have to look at the cards to see what is out and they look at the top right to see how much HP everything has... wait you did that with the Mobile Defense Platform so it is possible.
I didn't like the fact that you couldn't see all targets in play in the top right summary, if you are going to use that then put everything that has HP on there. I don't want to think I can hit Baron Blade and then find out when I select my power that the MDP wasn't quiet as dead as the previous player thought it was.
Also, is there a way to choose a different power if you misclick? (mistouch just sounds wrong)
The nemesis bonus was not applied when Legacy took a hit
Baron Blade's trash read 0s at the start of his second turn, and 2 at the end, it should have read 2 the whole way through (first turn Slash & Burn and a destroyed platform).
I also noticed that the text on Pushing the Limits is not up to date (and Sonic Vortex now that I look back at it).
EDIT:
Don't walk away thinking I was disappointed in it, it looks awesome and will be happy to buy it if/when a multiplatform/multiplayer aspect is added!