I'm finally jumping into this thread and saying what I have to say (and haven't already said in comments on posts) about all the information we now have.
1. Christopher's personality, as demonstrated in the podcast, brings me great joy. He clearly hasn't "gone corporate" at all; he's a total goober who's absolutely thrilled to have found an audience, not because he loves the attention but because he likes making others happy and creating something that they really like.
2. I couldn't help but notice that Prime Wardens Fanatic has an extremely prominent, er, pelvic area. It makes it a bit difficult for me to pay attention to the rest of her art. (Not in a sex-pervert sense, but just like a what-the-hell-is-she-wearing-with-a-figure-like-that-and-posing-in-such-a-way kind of reaction.)
3. Omnitron-IV is awesome. I said that already in comments, and others have said it here, but it bears repeating.
4. Deadline, Progeny, and Kaargra Warfang. That's 3 of the 4 villains we have names for, and assuming that Progeny is the guy on Reveal the Flaws (which seems sensible to assume), we've also seen them all. That means one villain remains who's a complete mystery. Maybe, just maybe, it's Captain Cosmic's evil brother?
5. We now know that one environment is Dok'Thorak, while the other is almost certainly that alien arena. I'm a little dissapointed that we won't have the ability to fight actually in space, with zero gravity and zero air and so forth; I was figuring one environment would probably be an asteroid belt or the wreckage of a destroyed planet or something. But oh well.
6. Sky-Scraper is really interesting to think about, given the reveal that she has multiple character cards for her sizes. Since these all have different Powers, I'm guessing that she'll use cards to change, essentially being the opposite of the Naturalist in that regard. Thusly, you might have cards like "Sky-Scraper becomes Huge, then deals one target 5 melee damage", or "Prevent the next 3 damage that would be dealt to Sky-Scraper; when damage is prevented this way, she becomes Tiny". It's also neat that her incap powers will differ depending on what size she was when she fell; I'd imagine that if she dies Huge, she offers large amounts of damage reduction by virtue of the idea that the heroes can literally hide behind her body. Whereas if she's defeated while Tiny, maybe she's shrunk to microscopic size and hiding in the villain's ear canal, so she can disturb his balance and reduce the damage he deals by 1 per instance, rather than protecting specific heroes from big heavy hits.