Mint.
I think all versions of Spite are poorly designed for the theme, because it’s almost always in your best interests to ignore the victims. At least Agent of Gloom Spite gives you a real incentive to save victims. Too bad the rules are written such that you still shouldn’t, because Spite normally turns over drugs faster than you can save victims. The mechanism only really works if there’s some way to force Spite to get (drugs + 2) victims in play.
Good Samaritan is one way to get that extra victim out, but that only works if Good Samaritan is one of the first 2 cards in play. In this game a Samaritan comes out on Spite’s 2nd turn... but that’s still too late, because trying for a save gets 5 victims under the safe house and a flipped Spite, which is bad.
I turned over the drugs in order, which meant I got the “take damage when your heroes use a power” drug immediately, and the -3 DR drug next. This severely cramped my ability to do damage, since most of the time my heroes would just get hurt while doing little or no damage themselves if they used a power. I did a fair number of “skip entire turn” plays to draw cards, which is never fun.
I did get a few hits in early via Fixer’s Driving Mantis, which meant Fixer would hit for nothing, but then he’d re-direct Spite’s retribution to himself for damage (since the DR only affects the 1st damage Spite takes per turn).
Eventually what turned the tide for me was Imbued Fire + By Any Means, which gave +2 damage to Spite. Chrono Ranger was doing +3 because of The Ultimate Target, and wasn’t having a problem with DR because he was using the Masada.
The deck-milling effect of the “hurt yourself” drug was highly beneficial. It put everyone’s equipment into the trash quickly, which Mr. Fixer turned into mass card draw via Salvage Yard. Chrono Ranger got all of his bounty cards early via Bounty Board.
Liberal use of Grease Gun, Ground Pound, and Alchemical Redirection were vital to keeping everyone alive. Ra was down to 6 at one point, but recovered via Staff plays.
Gloomweaver was easy, because Chrono Ranger was completely set up by that point. I refused to risk Hunter and Hunted until I could get some cover via Grease Guns etc., but once I had it, he did a preposterous amount of damage. Things like “Eye on the Prize” became ridiculously powerful, letting me hit several targets for 6-8 damage each.
It helped that the Trial of FIre came out and Ra made everyone immune to fire while adding +1 damage to all fire attacks. Since Trial of Fire isn’t a target, it wasn’t turned off by Grease Gun.