Talk about unexpected combinations -- the entire team (Sentinels, SS Tachyon, Grandpa Legacy, PW Fanatic, AA) for the latest one-shot (#66) is a combination machine!
Between Grandpa Legacy, Fanatic, and AA (assuming he gets the right instruments/songs in play), you can have three instances of multiple power usages every turn....and once the Sentinels get Human Shield in play, every time you give them a power usage, it's essentially a -1 DR for every hero target.
Add onto that the fact that the Sentinels' deck is *80%* one-shots (32 cards out of 40), and that makes them a ripe target for SS Tachyon's base power -- they can quickly get all out all of their Signature cards and Ongoings.
So, once you add Sentinels Tactics to the mix -- allowing the Sentinels to use a power the first time they do damage every turn, then here's an example of a totally overpowered hero turn:
Grandpa Legacy
Play: (whatever card he wants)
Power: Gung-Ho -- allowing another hero to heal 1 HP and use a power; so use it on...
...(ex:) PW Fanatic, who gladly takes the +1 HP, then uses *her* base power to get a free card play and let another hero use a power...
...(ex:) AA, if he has out instruments/songs that allow other heros to use a power, plus whatever additional goodies his instruments songs can do, so allow another hero to use a power, like...
...(ex:) SS Tachyon, who can use *her* base power to allow the Sentinels to (probably) play the bottom two cards of their deck. Since these are usually one-shots, and most of them do damage of some kind, then Sentinel Tactics will allow Mainstay to use his -1 DR power.
...Lather/rinse/repeat once you get to Fanatic and AA's turns. By the end of the heroes' turns, what you've likely accumulated is:
--3 extra card plays from Fanatic
--3 HP of healing (from Grandpa Legacy) distributed among Fanatic, AA, Tach, and/or the Sentinels.
--*6* extra card plays from the Sentinels (assuming every Experiment resulted in two card plays)
--whatever extras AA's instruments/songs are set up for (card draws, damage buff/reduction, etc.)
--the ability to redirect *any* damage from a hero target to a -3DR Mainstay (-4DR if he has his Chains out)...which means that PW Fanatic *wont* hurt herself when she uses her base power. But it's optional, so AA can still (ex:) take the damage from Polyphonic Flare, Tachyon can still take the damage from Pushing the Limits, etc., and if you get a villain that deals out irreducible AOE damage, you can opt not to get Mainstay killed. This may be the best tanking setup in the game; it costs 2 discards a round, but the Sentinels have fantastic card draw, so it's not a hardship.