i see you need a setback guide
let me tell you about setback
(by the way, I say all this as an online version player, so this may not 100% work with the physical cards. if it does, oh my goodness it's worse than i thought.)
1) "Living Battery Ram"
"Silver Lining" + "Friendly Fire" + "Looking Up" -> Destroyed upon reaching 10 Tokens via any friendly fire card that destroys ongoing OR "Whoops, Sorry!", then lead into reckless abandon upon getting a healthy number with "Reckless Rush" + "High Risk Behavior". Setback will likely go down, and go down hard, but you'll end up with a huge health bust, especially if your friends have been helping. This combo IS NOT helpful when you're with Legacy, Ra, etc. - generally characters that boost damage output, as Setback only needs to be hit for two on "Friendly Fire" and doing more is a very, very bad idea, especially if you're conserving HP and you have yet to reach 20+ Tokens on Set Back... but is nessecary to get the most out of Setback for this combo.
By doing this Setback can land about 10+ damage on a target at a time, and by boosting the effect with cards like "Inspiring Prescence" + Power: Galvinize, "Imbuded Fire" (especially when dealing with Voss or another Villain that negates Melee damage, which is the only type Setback can do), and etc., while he'll knock himself out really quickly, he'll get back up and only need to build up tokens again. Pair him up with people who can heal, like Captain Cosmic, the Argent Adept, Tempest, and heal him multiple times per turn, and you've got a horrifying chaos.
So, tl;dr: "Friendly Fire" + "Looking Up" (destroyed when it's safe) + "High Risk Behavior" + "Silver Lining", pair Setback up with (at best) Legacy, Ra, Tempest, Argent Adept, Captain Cosmic, the Wraith, or Expatriette (to hit Friendly Fire multiple times per turn thanks to Unload), and then praying you shuffled that deck just right.
Remember that Setback's Max HP is 31 and that's already really high. When you're hitting around 25 Tokens on that "Silver Lining" back up, it's a good time to think about using cards like "Exceed Expectations", "Plucky Break", "Turn of Events", etc.
2) "I'm just a magnet for trouble!"
Abuse the text. AKA: get a cycle going through sheer fortune alone. That's basically what Setback's power is all about. It's really stupid, yes, but there's ways AROUND it that are just absolutely nessecary.
Pair "Uncharmed Life" with "Wrong Time and Place", but you'll need to abuse and constantly spam "Looking Up", "High Risk Behavior", "Friendly Fire", "Reckless Rush", AND "Surprising Fortune". Because the first two rely on you removing tokens, you cannot just put "Silver Lining" down and expect a high pay-off at the end and reap rewards unless, of course, Setback's fortune comes back in your favor. You'll basically be constantly balancing his checkbook of tokens and you'll actually feel like gambling.
"Cause and Effect" and "Plucky Break" give bonuses if you have 0 tokens, while "Karmic Retribution" removes exactly 1 token if you have less than 7 (otherwise, it removes 7, which is really bad for this set-up). You constantly need Tokens on him anyway, so make a note of every card written in Strat 1 because those all give +Tokens.
Remember though: Setback wouldn't be a setback if he wasn't luck based. At the very least though, you'll be redirecting damage and should it get too much, you can disarm him and take a break, and switch tactics or rely on the same team as above or The Scholar to heal you.
Additional: Dark Watch Setback
(Note: I have not had the chance to play with DW!Setback, so this is all theoretical just by judging from the power and his deck.)
DW!Setback's power is the opposite of Standard Setback, in that he removes a token, not gains one. At that cost however, Setback boosts a Hero's defense by 2. Dark Watch Setback is, as a result, more support oriented while Setback can play either/or. He's more open to playing heavier hitters and could, with proper care and power abuse through the help of the Argent Adapt, Captain Cosmic, and others who can force powers to be used out of turns like Guise, take on characters like The Chairman, La Capitan, and Akash'Bhuta with ease. Silver Lining won't balance very well, in theory, but again, he's entirely luck based - just less avidly. You'll just be doing more mental math and be required to plan ahead, as well as go "That was a setback" out loud more often.
Dark Watch Setback is better set up with someone who can draw heavy and have him pillage through his deck, allowing him to find a combo to set up to quickly farm some damage while also backing up a "Silver Lining" OR giving his team some support through HP heals, redirection, damage sponging or bonus powers. Because he can't do it by himself, he'll need someone like Super-Scientific Tachyon, Freedom Six Tachyon, again the Argent Adapt, or just pair him up with his actual team and have Nightmist use "Astral Premonition" whenever Setback just can't find the card he needs.
All in all: Setback can be broken down as either "reckless abandon" or "I brought sports drinks and towels for everyone". He's a less obvious Legacy, in my eyes - he can do both, and can do both really well, but you can also only go really one way or the other unless you want to build for a really, really long time.